late post : INTERNATIONAL SEMINAR ON NATURAL PRODUCT MEDICINE 2018

INTERNATIONAL SEMINAR ON NATURAL PRODUCT MEDICINE 2018

Sekolah Farmasi - Institut Teknologi Bandung

Bandung,  4-5 Oktober 2018

DEVELOPMENT OF BONE SCAFFOLD BASED ON HYDROXYAPATITE - CINCAU PECTIN BIOCOMPOSITE

Pectin extract results from green Cincau leaf (Premna oblongifolia Merr) using citric acid showed that the increase of citric acid concentration could increase the amount of yields and metoxyl content, but the equivalent weight decreased with the increase of citric acid concentration. While the degree of esterification is relatively low despite the increased concentration of citric acid, it is also supported by the results of observation with FTIR.

The observations by FTIR of the resulting pectin show there are carboxyl groups and metal groups of the ester and ether groups, as well as the C-O and C-OH bonds of the pyranose chain.  The result of morphological analysis and compressive strength of scaffold made by SEM observation, it still could not reach optimum and fragile pore size. The result of porosity analysis and the density of scaffold made has fulfilled the porosity range and sponge bone density and can experience degradation. The result also shows the difference of pore size between the surface part and the center of the scaffold where the surface part has a larger pore than the center of the scaffold.

Between HA and pectin, there appears ionic bonding and hydrogen bonding, however the HA-pectin scaffold has low strength. The results of degradation testing showed that there was an increase in degradation with increasing days of observation and reached the maximum degradation on day 14, after which degradation decreased.