INTERNATIONAL SEMINAR ON NATURAL
PRODUCT MEDICINE 2018
Sekolah Farmasi - Institut Teknologi Bandung
Bandung, 4-5 Oktober 2018
DEVELOPMENT OF BONE SCAFFOLD BASED ON HYDROXYAPATITE - CINCAU PECTIN BIOCOMPOSITE
Pectin
extract results from green Cincau leaf
(Premna oblongifolia Merr)
using citric acid showed that the increase of citric acid concentration could
increase the amount of yields and metoxyl
content, but the equivalent weight decreased with the increase of citric acid
concentration. While the degree of esterification is
relatively low despite the increased concentration of citric acid, it is also
supported by the results of observation with FTIR.
The
observations
by FTIR of the resulting pectin show there are carboxyl groups and metal groups
of the ester and ether groups, as well as the C-O and C-OH bonds of the pyranose
chain. The result of morphological
analysis and compressive strength of scaffold made by SEM observation, it still
could not reach optimum and fragile pore size. The result of porosity analysis
and the density of scaffold made has fulfilled the porosity range and sponge
bone density and can experience degradation. The result also shows the
difference of pore size between the surface part and the center of the scaffold
where the surface part has a larger pore than the center of the scaffold.
Between
HA
and pectin, there appears ionic bonding and hydrogen bonding, however the
HA-pectin scaffold has low strength. The results of degradation testing showed
that there was an increase in degradation with increasing days of observation
and reached the maximum degradation on day 14, after which degradation
decreased.